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Digoxin toxicity
Mechanism: - Inhibits Na/K ATPase pump - Leads to increased intracellular sodium - Results in increased intracellular calcium through sodium-calcium exchanger Risk Factors: - Renal impairment (digoxin is primarily cleared by kidneys) - Can occur even with: - Stable chronic dosing - Levels within therapeutic range - Hypokalemia (ie from ...
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